About Aquamin™ F Aquamin™ F is a brand name for a natural marine-derived multi-mineral complex produced by Marigot Ltd. This product is derived from calcareous marine algae (Lithothamnion sp.) that is harvested from the North Atlantic seabed. Aquamin™ F is rich in bioactive Calcium, Magnesium, and over 70 trace elements and has beneficial effects on bones, inflammation, especially osteoarthritic conditions, digestive health, and cardiovascular health. Over two decades, Marigot Ltd. has conducted independent research on Aquamin, involving in vitro assays, animal models, and human trials in collaboration with respected academic institutions worldwide. Researchers are encouraged to publish in peer-reviewed journals, ensuring transparency and scrutiny by peers. Studies Study 1 - A Natural, Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure, Composition and Strength in an Ovariectomised Rat Model of Osteoporosis Study details 88 female rats 20 weeks duration 4 treatment groups: Control, Ovariectomy + Calcium Carbonate, Ovariectomy + Aquamin, Ovariectomy + Aquamin Delay (started 8 weeks post OVX) Results The study demonstrates that supplementing Aquamin in the ovariectomy rats has remarkable preservation of bone fraction and whole bone strength in the proximal tibia of rats by week 20 compared to the ovariectomy rats fed Calcium Carbonate. Conclusion This study recommends the use of Aquamin as a supplement to help prevent bone loss in women after menopause. Fig 1: Percentage change in structural parameters in the metaphyseal proximal tibia for all groups over all time points. Fig 2: The mineral/matrix ratio was significantly reduced following 20 weeks of estrogen deficiency View Published Study Study 2 - Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women1, 2 Study details 300 healthy postmenopausal women 24 months duration, randomized, double-blind, controlled trial 3 treatment groups: Placebo, Aquamin, Aquamin + scFOS Measurements DEXA scans for bone mineral density (BMD) at the beginning and the end Bone turnover markers (BTM) measured at 0, 12 and 24 months. Results While the change in BMD was similar among the groups, the greater decrease in BTMs in the Ca (Aquamin) and CaFOS groups, in comparison to the Placebo group, indicates a potentially more beneficial impact on bone health following supplementation with Ca and CaFOS. The supplementation of CaFOS was found to slow down the rate of bone loss in both the entire body and the spine in postmenopausal women with osteopenia. This effect deserves further research and exploration. Fig 1: DEXA scans for BMD after 24 months Fig 2: Changes in BTM at baseline and after 12 and 24 months View Published Study Study 3 - Effect of Calcium Derived from Lithothamnion sp. on Markers of Calcium Metabolism in Premenopausal Women Study details 12 fasting females received a single dose of 720mg of Aquamin F (derived from the marine algal Lithothamnion sp.), 720 mg of Calcium Carbonate, or Placebo Measurements The samples of blood and urine were collected at baseline and after 12 hours to assess levels of ionized and total Calcium and parathyroid hormone (PTH) levels. Results Females received Aquamin F treatment demonstrated significantly greater urinary clearance of Calcium after 12 hours compared with placebo. Females received Aquamin F treatment demonstrated a prolonged suppression of serum PTH concentration (significantly lower than placebo at 90, 120 and 240 minutes). Calcium Carbonate had a modest impact, with no significant difference in urinary clearance compared to the placebo and PTH levels were significantly lower than the placebo at 90 minutes. Hence, Aquamin F has a stronger effect on Calcium metabolism markers than Calcium Carbonate or placebo after a meal in premenopausal women. Fig 1: Percent change in serum PTH levels over time. View Published Study Study 4 - Calcium Supplementation and Parathyroid Hormone Response to Vigorous Walking in Postmenopausal Women Study details Group A: 10 women consumed 125 mL of either a Ca-fortified (1000mg of Aquamin) or control beverage (no Ca) every 15 minutes during exercise, starting 60 minutes before and continuing during 60 minutes of exercise (1 L total over 2 hours). Group B: 23 women consumed 200 mL of either a Ca-fortified (1000mg of Aquamin) or control beverage (no Ca) every 15 minutes during exercise, starting 15 minutes before and continuing during 60 minutes of exercise (1 L total over 1.25 hours). The exercise was treadmill walking at 75%-80% VO2peak. Results In Group A, Aquamin prevented Calcium decrease and reduced PTH and CTX (bone resorption (C-terminal telopeptides of type I collagen)) increases when consumption began 1 hour before exercise. In Group B, Aquamin also prevented Calcium decrease but did not affect PTH and CTX increases when consumption began 15 minutes before exercise. These results indicate that consuming Aquamin one hour before and during exercise could potentially protect post-menopausal women from experiencing decreased bone density associated with exercise. Fig 1: Serum ionized Ca (iCa) before, during, and after exercise (left) under control and Ca supplementation conditions and the change from immediately before to immediately after exercise (right). Fig 2: Serum PTH before, during, and after exercise (left) under control and Ca supplementation conditions and the change from immediately before to immediately after exercise (right). Fig 3: Serum CTX before, during, and after exercise (left) under control and Ca supplementation conditions and the change from immediately before to 30 min after exercise (right). View Published Study Study 5 - Magnesium Supplementation through Seaweed Calcium Extract Rather than Synthetic Magnesium Oxide Improves Femur Bone Mineral Density and Strength in Ovariectomized Rats Study details 40 Sprague–Dawley female rats 12 weeks duration Divided into 4 groups: Sham (0.50% Ca + 0.05% Mg), Ovariectomized (OVX) (0.50% Ca + 0.05% Mg), Ovariectomized + Ca & Mag (OVX-Mg) (0.50% Ca + 0.10% Mg), Ovariectomized + Seaweed Ca & Mag (OVX-SCa) (0.50% Ca Aquamin + 0.10% Mg Aquamin & Mg Oxide) Results OVX-SCa rats have improved femur strength compared to OVX and OVX-Mg rats. Femur bone mineral and bone area are similar in two groups of OVS-SCa and Sham rats. Meanwhile, OVX and OVX-Mg rats had lower. Table 1: Bone status of the experimental rats View Published Study More Published Articles
