About DE111® DE111® is a Bacillus subtilis probiotic that helps balance gut microbiota. It aids in the natural immune responses of intestinal cells and contributes to the preservation of the gut barrier's integrity. DE111® probiotics offer benefits to the gut, an integral part of the body's connection with the brain and the rest of the body. The advantages of Bacillus subtilis probiotic DE111® are firmly substantiated, backed by the team of experts at Deerland Probiotics & Enzymes, Inc., and verified through IRB-approved, double-blind, randomized, and placebo-controlled clinical trials. Studies Study 1 - Effect of Daily Bacillus subtilis DE111® Intake on Children’s GI Health Study details 81 kids aged 2-6 Divided into 2 random groups: Bacillus subtilis DE111® (1 × 10^9 CFU) and a fake pill (placebo) daily 8 weeks duration Results Analysis of the ITT population showed a trend of reduction in both the incidence of Gastrointestinal Infections (GII). Other symptoms, including vomiting, hard stools, and overall stomach discomfort showed a reduction for the group that was taking DE111 sIgA levels went up more in the placebo group than in the probiotic group. Conclusion Consuming B. subtilis DE111® probiotic is safe for children and contributes to maintaining a healthy gastrointestinal system. Table 1: Incidence of Respiratory Infections (RI) and Gastrointestinal Infections (GII) and symptoms during the 8-week intervention period. Fig 1: Boxplot of salivary IgA values at baseline (white) and after 8 weeks of intervention (dotted). Braces denote statistically significant difference. O Circles represent data outliers. View Published Study Study 2 - Examining the Gastrointestinal and Immunomodulatory Effects of the Novel Probiotic Bacillus subtilis DE111 Study details 46 participants aged 26-60 Divided into 2 random groups: DE111 and placebo 4 weeks duration Results A significant decrease related to gastric function in the DE111 group compared to the Placebo group from baseline to post-intervention Significant decreases in CD3 + T cells, CD25+FoxP3+ T, cytotoxic T cells, and NKT cells Conclusion The study indicates that DE111 may influence the immune system by affecting both innate (immediate response) and adaptive (delayed response) types of immune cells. Fig 1: Symptom severity scores to gastric function Fig 2: Basal immune status at baseline and post-intervention in Placebo and DE111 groups View Published Study
